The effect of massive doses of cortisone on the peripheral blood and bone marrow of the mouse.

AND WILLIAM ANTON)L, M.D. D URING THE COURSE of studying the effects of massive doses of cortisone on mice, it was noted that a pronounced lymphoid hypoplasia and a lymphopenia in the peripheral blood occurred.’ In view of these findings a study of the total blood eosinophils, lymphocytes and granulocytes and hemoglobin was made. The first two of these blood elements have been shown to decrease in number after the administration of adrenal cortical substances.2 ‘